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VIAGRA (sildenafil citrate), an oral treatment for erectile brokenness, is the citrate salt of sildenafil, a particular inhibitor of cyclic guanosine monophosphate (cGMP)- explicit phosphodiesterase type 5 (PDE5).
Sildenafil citrate is assigned synthetically as 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3d]pyrimidin-5-yl)- 4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate and has the accompanying primary formula:Sildenafil citrate is a white to grayish translucent powder with a dissolvability of 3.5 mg/mL in water and an atomic load of 666.7.
VIAGRA is formed as blue, film-covered adjusted jewel molded tablets identical to 25 mg, 50 mg and 100 mg of sildenafil for oral organization. Notwithstanding the dynamic fixing, sildenafil citrate, every tablet contains the accompanying dormant fixings: microcrystalline cellulose, anhydrous dibasic calcium phosphate, croscarmellose sodium, magnesium stearate, hypromellose, titanium dioxide, lactose, triacetin, and FD and C Blue #2 aluminum lake.
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VIAGRA is shown for the treatment of erectile brokenness.
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DOSAGE AND ADMINISTRATION
For most patients, the suggested portion is 50 mg taken, depending on the situation, roughly 1 hour before sexual action. Be that as it may, VIAGRA might be taken somewhere in the range of 30 minutes to 4 hours before sexual action. The most extreme suggested dosing recurrence is one time each day.
In light of adequacy and lenience, the portion might be expanded to a greatest suggested portion of 100 mg or diminished to 25 mg.
Use With Food
VIAGRA might be taken with or without food.
Dose Adjustments In Specific Situations
VIAGRA was displayed to potentiate the hypotensive impacts of nitrates and its organization in patients who utilize nitric oxide givers, for example, natural nitrates or natural nitrites in any structure is in this manner contraindicated [see CONTRAINDICATIONS, DRUG INTERACTIONS, and CLINICAL PHARMACOLOGY].
At the point when VIAGRA is co-controlled with an alpha-blocker, patients ought to be steady on alpha-blocker treatment preceding starting VIAGRA treatment and VIAGRA ought to be started at 25 mg [see WARNINGS AND PRECAUTIONS, DRUG INTERACTIONS, and CLINICAL PHARMACOLOGY].
Dose Adjustments Due To Drug Interactions
The suggested portion for ritonavir-treated patients is 25 mg before sexual action and the suggested most extreme portion is 25 mg inside a 48 hour time span since attending organization expanded the blood levels of sildenafil by 11-overlap [see WARNINGS AND PRECAUTIONS, DRUG INTERACTIONS, and CLINICAL PHARMACOLOGY].
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Dosage Forms And Strengths
VIAGRA is provided as blue, film-covered, adjusted precious stone formed tablets containing sildenafil citrate comparable to 25 mg, 50 mg, or 100 mg of sildenafil. Tablets are debossed with PFIZER on one side and VGR25, VGR50 or VGR100 on the other to show the measurements qualities.
Capacity And Handling
VIAGRA (sildenafil citrate) is provided as blue, film-covered, adjusted precious stone molded tablets containing sildenafil citrate identical to the ostensibly showed measure of sildenafil and debossed on the front and converse sides
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The most widely recognized unfavorable responses announced in clinical preliminaries ( > 2%) are migraine, flushing, dyspepsia, strange vision, nasal clog, back torment, myalgia, sickness, wooziness, and rash.
Clinical Trials Experience
Since clinical preliminaries are led under generally shifting conditions, unfriendly response rates saw in the clinical preliminaries of a medication can’t be straightforwardly contrasted with rates in the clinical preliminaries of another medication and may not mirror the rates saw in clinical practice.
VIAGRA was regulated to more than 3700 patients (matured 19-87 years) during pre-showcasing clinical preliminaries around the world. North of 550 patients were treated for longer than one year.
in fake treatment controlled clinical examinations, the end rate because of unfriendly responses for VIAGRA (2.5%) was not fundamentally not the same as fake treatment (2.3%).
In fixed-portion studies, the occurrence of some unfavorable responses expanded with portion. The sort of unfriendly responses in adaptable portion studies, which mirror the suggested dose routine, was like that for fixed-portion studies. At dosages over the suggested portion range, unfriendly responses were like those point by point in Table 1 underneath however by and large were accounted for all the more much of the time.
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There is a potential for heart hazard of sexual movement in patients with prior cardiovascular sickness. Accordingly, medicines for erectile brokenness, including VIAGRA, ought not be by and large utilized in individuals for whom sexual action is ill advised on account of their basic cardiovascular status. The assessment of erectile brokenness ought to incorporate an assurance of potential fundamental causes and the distinguishing proof of proper therapy following a total clinical evaluation.
VIAGRA has foundational vasodilatory properties that brought about transient declines in prostrate pulse in solid volunteers (mean greatest abatement of 8.4/5.5 mmHg), [see CLINICAL PHARMACOLOGY]. While this typically would be relied upon to be unimportant in many patients, before endorsing VIAGRA, doctors ought to painstakingly consider whether their patients with basic cardiovascular illness could be impacted unfavorably by such vasodilatory impacts, particularly in mix with sexual movement.
Use with alert in patients with the accompanying basic conditions which can be especially touchy to the activities of vasodilators incorporating VIAGRA those with left ventricular surge deterrent (e.g., aortic stenosis, idiopathic hypertrophic subaortic stenosis) and those with seriously impeded autonomic control of circulatory strain.
There are no controlled clinical information on the security or viability of VIAGRA in the accompanying gatherings; whenever recommended, this ought to be finished with alert.
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